I'm a 6'2" / 210 lb road racer with 29" thighs, and have never had a set of wheels last me more than 5 months - except my pair of American Classic 350 Deep-Vs. They are 28/32 and factory-built. I've blown apart Rolf Vector Pros, HED 3 (carbon tri-spoke), Spinergy Xaero and XaeroLites, and Ksyriums. The Deep-Vs aren't particularly aero nor stinko light, but they roll smoothly, are torsionally stiff, can be serviced anywhere, and are bomb-proof.
For a lighter wheel that's more durable than most, try Topolinos. Although I did turf my Topos eventually, they are ridiculously light, have terrific hubs, stay remarkably true under mondo punishment, have a very cushy ride due to the soft spokes, and the guys at Topolino are great about tech support. When I finally sproinged my front Topolino, I sent my pair back to Topo for a rebuild with different nipples and higher spoke tensions. I recently got them back, took them out for a ride, and went "aaaaahhhhhhhhhh". They are the best-riding wheel I've tried, and I've tried almost everything, because my team gets lots of demo wheels.
Topos really are a unique and remarkable wheel, take it from a gorilla wheel mangler who can break anything. I have taco-ed titanium cassettes, I break a chain about once a month, I have torn through steel frame tubes from sprinting, and the driveway to my house is a 21-degree incline, so just riding home is an acid test for drive train components.
-------------------- "I haven't failed. I've just managed to find 100,000 ways that don't work"
--Albert Einstein
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