I'd heard good things about the Eurus and Neutron wheels and wanted to give them a try. They're not silly-lightweight like the Topolinos so I hope they're a little more durable. My LBS recommended the Neutron over the Eurus for me (6'5" 190#) with it's 22/24 spoke count to Eurus' 16/22 and a little heavier and hopefully more durable. Neutrons/Eurus' didn't have such a mixed love/hate following like Ksyrium wheels do.
I considered Fulcrum wheels as well. After the minor issues with the Topolinos and the broken spoke I didn't want to depend on them not breaking again on the new bike. The rest of the components are Campy as well so that helped the decision a tiny bit.
On top of that I've had the new bike for 2 weeks now and I'm still waiting for the Topolino wheel to come back from repairs. If I'd stuck with them for the new bike, I'd still be waiting to ride it instead of 450 miles into enjoying it.
FWIW, I don't think the Topolinos (or any wheel really) will smooth the road out as much as your tires will. I'm trying to find a good balance between slightly lower pressure in my tires and preventing snake bite flats from under-inflation. I used to run 100psi, but now I'm playing with 110. I read an article on roadbikerider.com that made a case for riding with 80 - 90 psi, but I suspect that I'd have a lot of flats if I went that low at my size